Starvation of cancer via induced ketogenesis and severe hypoglycemia.

  title={Starvation of cancer via induced ketogenesis and severe hypoglycemia.},
  author={Adam Kapelner and Matthew Vorsanger},
  journal={Medical hypotheses},
  volume={84 3},

Figures and Tables from this paper

Is It Possible To Induce The "Spontaneous Regression" Of Cancer? A Mechanism of Activation for the Innate Immune Response
A theoretical model of the mechanism of the spontaneous regression of tumor, involving the activation of innate immune response, explains the cases of spontaneous regression described in literature and could be easily verified experimentally.
Cancerous glucose metabolism in lung cancer—evidence from exhaled breath analysis
The volatile signature in lung cancer (LC) before and after an oral glucose tolerance test (OGTT) is investigated to determine if tumor cells’ hyperglycolysis would affect the volatile signature, and it is hypothesized that a ceiling effect in cancerous patients is responsible for this discrepancy.
The findings demonstrate that adipose vasculatures show differential responses to anti-VEGF treatment in various age populations and have therapeutic implications for treatment of obesity and diabetes with antiVEGF-based drugs.
Ketogenic diet and childhood neurological disorders other than epilepsy: an overview
KD could improve cognitive and social skills in a subset of children with ASD, and its potential use as co-adjuvant and alternative therapeutic option for brain cancer, while any beneficial effect of KD on migraine remains unclear.
A systematic review of the use of ketogenic diets in adult patients with cancer
High-quality evidence on the effect of ketogenic diets on anthropometry, metabolism, quality of life (QoL) and tumour effects is currently lacking in oncology patients, highlighting the need for controlled trials to fully evaluate the intervention.
Association between a High-fat Low-carbohydrate Diet and Non-alcoholic Fatty Liver Disease: Truth or Myth?
While many cross-sectional studies have investigated specialized diet programs for patients with non-alcoholic liver disease, no random-ized controlled studies have been performed, except for some that investigated the effect of high consumption of unsaturated fatty acids as part of the Mediterranean diet.
Alternative Ketogenic Diet with Coconut Milk in a Case with Underlying Colorectal Cancer
This work confirmed the molecular classification of diffuse large B‐cell lymphoma by immunohistochemistry using a tissue microarray as non‐Hodgkin’s lymphoma, which shows a non‐germinal center B‐ cell phenotype.
Toxoplasmosis and Lymphoma: The Mimickers
  • M. Abdulla, Hazwa K. Hamza
  • Medicine
    Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric Oncology
  • 2017
With nutritional modifications, the patient successfully has a ketogenic diet with above average blood sugar and the patient developed calf muscle pain and cramp in his legs.
Spontaneous Regression of Clear Cell Carcinoma of the Endometrium
This report documents a rare case of complete spontaneous regression of clear cell carcinoma of the endometrium of an elderly woman with paranoid schizophrenia who was admitted to the hospital because of vaginal bleeding and later died of a natural cause.


Role of glucose and ketone bodies in the metabolic control of experimental brain cancer
The results in a mouse astrocytoma suggest that malignant brain tumours are potentially manageable with dietary therapies that reduce glucose and elevate ketone bodies.
Ketoacids? Good medicine?
  • G. Cahill, R. Veech
  • Biology
    Transactions of the American Clinical and Climatological Association
  • 2003
D-beta-hydroxybutyrate, the principal "ketone" body in starving man, displaces glucose as the predominating fuel for brain, decreasing the need for glucose synthesis in liver (and kidney) and
Ketogenic Diet in Advanced Cancer: A Pilot Feasibility and Safety Trial in the Veterans Affairs Cancer Patient Population
A pilot study to examine the safety and tolerability of the ketogenic diet KD in patients with advanced cancer within the Veteran Affairs Pittsburgh Healthcare System (VAPHS) oncology patient population is conducted.
The Ketogenic Diet and Hyperbaric Oxygen Therapy Prolong Survival in Mice with Systemic Metastatic Cancer
KD and HBO2T produce significant anti-cancer effects when combined in a natural model of systemic metastatic cancer, and the evidence suggests that these therapies should be further investigated as potential non-toxic treatments or adjuvant therapies to standard care for patients with systemic metastasis disease.
The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid β-oxidation
It is suggested that activation of Akt blocks the ability of cancer cells to metabolize nonglycolytic bioenergetic substrates, leading to glucose addiction.
The ketogenic diet reverses gene expression patterns and reduces reactive oxygen species levels when used as an adjuvant therapy for glioma
The data demonstrate that the ketogenic diet improves survivability in a mouse model of glioma, and suggests that the mechanisms accounting for this protective effect likely involve complex alterations in cellular metabolism beyond simply a reduction in glucose.
Ketone bodies inhibit the viability of human neuroblastoma cells.
Choosing between glycolysis and oxidative phosphorylation: a tumor's dilemma?
The ketogenic diet for the treatment of malignant glioma
The ketogenic diet (high fat, low carbohydrate and protein), caloric restriction, and fasting all cause a metabolic change, specifically, a reduction in blood glucose and an increase in blood ketones and it is demonstrated that these metabolic changes improve survival in animal models of malignant gliomas and can potentiate the anti-tumor effect of chemotherapies and radiation treatment.
Ketogenic Diets Enhance Oxidative Stress and Radio-Chemo-Therapy Responses in Lung Cancer Xenografts
Results show that a ketogenic diet enhances radio-chemo-therapy responses in lung cancer xenografts by a mechanism that may involve increased oxidative stress.