Starvation-induced activation of ATM/Chk2/p53 signaling sensitizes cancer cells to cisplatin

@inproceedings{Shi2012StarvationinducedAO,
  title={Starvation-induced activation of ATM/Chk2/p53 signaling sensitizes cancer cells to cisplatin},
  author={Yandong Shi and Emanuela Felley-Bosco and Thomas Michael Marti and Katrin Orlowski and Martin N Pruschy and Rolf Arno Stahel},
  booktitle={BMC Cancer},
  year={2012}
}
Optimizing the safety and efficacy of standard chemotherapeutic agents such as cisplatin (CDDP) is of clinical relevance. Serum starvation in vitro and short-term food starvation in vivo both stress cells by the sudden depletion of paracrine growth stimulation. The effects of serum starvation on CDDP toxicity were investigated in normal and cancer cells by assessing proliferation, cell cycle distribution and activation of DNA-damage response and of AMPK, and were compared to effects observed in… CONTINUE READING
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