Starvation-induced activation of ATM/Chk2/p53 signaling sensitizes cancer cells to cisplatin

Abstract

Optimizing the safety and efficacy of standard chemotherapeutic agents such as cisplatin (CDDP) is of clinical relevance. Serum starvation in vitro and short-term food starvation in vivo both stress cells by the sudden depletion of paracrine growth stimulation. The effects of serum starvation on CDDP toxicity were investigated in normal and cancer cells by… (More)
DOI: 10.1186/1471-2407-12-571

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