Starvation and triglycerides reverse the obesity-induced impairment of insulin transport at the blood-brain barrier.

@article{Urayama2008StarvationAT,
  title={Starvation and triglycerides reverse the obesity-induced impairment of insulin transport at the blood-brain barrier.},
  author={Akihiko Urayama and W. A. Banks},
  journal={Endocrinology},
  year={2008},
  volume={149 7},
  pages={3592-7}
}
Insulin in the brain acts as a satiety factor, reduces appetite, and decreases body mass. Altered sensing by brain of insulin may be a leading cause of weight gain and insulin resistance. A decrease in the transport across the blood-brain barrier (BBB) of insulin may induce brain insulin resistance by inducing obesity. We here report that transport of iv administrated insulin across the BBB of obese mice, as measured by multiple-time regression analysis, was significantly lower than that in… CONTINUE READING