Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes

@article{Young2006StarvationAU,
  title={Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes},
  author={Andrew Young and Edmond Y. W. Chan and Xiao Wen Hu and Robert K{\"o}chl and Samuel G. Crawshaw and Stephen High and Dale Warren Hailey and Jennifer Lippincott-Schwartz and Sharon A. Tooze},
  journal={Journal of Cell Science},
  year={2006},
  volume={119},
  pages={3888 - 3900}
}
Autophagy, fundamentally a lysosomal degradation pathway, functions in cells during normal growth and certain pathological conditions, including starvation, to maintain homeostasis. Autophagosomes are formed through a mechanism that is not well understood, despite the identification of many genes required for autophagy. We have studied the mammalian homologue of Atg9p, a multi-spanning transmembrane protein essential in yeast for autophagy, to gain a better understanding of the function of this… Expand
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