Stargazin reduces desensitization and slows deactivation of the AMPA-type glutamate receptors.

@article{Priel2005StargazinRD,
  title={Stargazin reduces desensitization and slows deactivation of the AMPA-type glutamate receptors.},
  author={Avi Priel and Alexander Kolleker and Gai Ayalon and Moshe Gillor and Pavel Osten and Yael Stern-Bach},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2005},
  volume={25 10},
  pages={2682-6}
}
The AMPA-type glutamate receptors mediate the majority of the fast excitatory synaptic transmission and critically contribute to synaptic plasticity in the brain, hence the existence of numerous trafficking proteins dedicated to regulation of their synaptic delivery and turnover. Stargazin (also termed gamma2) is a member of a recently identified protein family termed transmembrane AMPA receptor regulatory proteins (TARPs). TARPs physically associate with AMPA receptors and participate in their… CONTINUE READING
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