Starch microspheres induce pulsatile delivery of drugs and peptides across the epithelial barrier by reversible separation of the tight junctions.

@article{Bjrk1995StarchMI,
  title={Starch microspheres induce pulsatile delivery of drugs and peptides across the epithelial barrier by reversible separation of the tight junctions.},
  author={Elisabeth Bj{\"o}rk and Ulf Isaksson and Pehr Edman and Per Artursson},
  journal={Journal of drug targeting},
  year={1995},
  volume={2 6},
  pages={501-7}
}
Non-parenteral administration of peptide drugs is prevented by the limited permeability of the epithelia lining the mucosal tissues. As a new approach to non-parenteral delivery, degradable starch microspheres (dsm) were coated with insulin and administered to the mucosal side of monolayers of human intestinal epithelial (Caco-2) cells in vitro. The microspheres induced a pulsed delivery of insulin across the epithelium that lasted for 1-2 h. The pulsed delivery correlated with a reversible… CONTINUE READING