Star-Shaped Tetraspermine Enhances Cellular Uptake and Cytotoxicity of T-Oligo in Prostate Cancer Cells

@article{Kolhatkar2014StarShapedTE,
  title={Star-Shaped Tetraspermine Enhances Cellular Uptake and Cytotoxicity of T-Oligo in Prostate Cancer Cells},
  author={Vidula R. Kolhatkar and Hiren Khambati and Asawari R. Lote and Peter Shanine and Thomas Insley and Soumyo Sen and Gnanasekar Munirathinam and Petr Kr{\'a}l and Rohit Kolhatkar},
  journal={Pharmaceutical Research},
  year={2014},
  volume={32},
  pages={196-210}
}
An oligonucleotide termed ‘T-oligo’ having sequence homology with telomere overhang has shown cytotoxicity in multiple cancers. We have demonstrated that T-oligo can induce apoptosis in androgen independent prostate cancer cell line DU-145. In this report, we evaluate the use of star-shaped tetraspermine (SSTS) for delivery of T-oligo. SSTS was synthesized from spermine and its intrinsic cytotoxicity towards DU-145 cells was compared with spermine and branched polyethyleneimine (bPEI… CONTINUE READING
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