Star-Graft Quarterpolymer-Based Polymersomes as Nanocarriers for Co-Delivery of Hydrophilic/Hydrophobic Chemotherapeutic Agents

@inproceedings{Iatridi2018StarGraftQP,
  title={Star-Graft Quarterpolymer-Based Polymersomes as Nanocarriers
for Co-Delivery of Hydrophilic/Hydrophobic Chemotherapeutic Agents},
  author={Zacharoula Iatridi and Athina Angelopoulou and Efstathia Voulgari and Konstantinos Avgoustakis and Constantinos Tsitsilianis},
  booktitle={ACS omega},
  year={2018}
}
We report the fabrication of polymersomes, using as building blocks star-graft quarterpolymers, composed of hydrophobic polystyrene and pH-sensitive poly(2-vinylpyridine)-b-poly(acrylic acid) (P2VP-b-PAA) arms, emanated from a common nodule, enriched by thermosensitive poly(N-isopropylacrylamide) grafts covalently bonded on the PAA block-arms. These multicompartmental polymersomes were evaluated as nanocarriers for the encapsulation and controlled co-delivery of doxorubicin (hydrophilic) and… CONTINUE READING
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