Staphylococcus quorum sensing in biofilm formation and infection.

  title={Staphylococcus quorum sensing in biofilm formation and infection.},
  author={Kok-Fai Kong and Cuong Vuong and Michael Otto},
  journal={International journal of medical microbiology : IJMM},
  volume={296 2-3},
Cell population density-dependent regulation of gene expression is an important determinant of bacterial pathogenesis. Staphylococci have two quorum-sensing (QS) systems. The accessory gene regulator (agr) is genus specific and uses a post-translationally modified peptide as an autoinducing signal. In the pathogens Staphylococcus aureus and Staphylococcus epidermidis, agr controls the expression of a series of toxins and virulence factors and the interaction with the innate immune system… CONTINUE READING

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