Staphylococcus epidermidis is cleared from biomaterial implants but persists in peri-implant tissue in mice despite rifampicin/vancomycin treatment.

@article{Broekhuizen2008StaphylococcusEI,
  title={Staphylococcus epidermidis is cleared from biomaterial implants but persists in peri-implant tissue in mice despite rifampicin/vancomycin treatment.},
  author={Corine A N Broekhuizen and Leonie de Boer and Kim Schipper and Christopher D. Jones and Shan Quadir and Christina M. J. E. Vandenbroucke-Grauls and Sebastiaan A J Zaat},
  journal={Journal of biomedical materials research. Part A},
  year={2008},
  volume={85 2},
  pages={498-505}
}
Infections associated with implanted biomedical devices (BAI) are predominantly caused by Staphylococcus epidermidis. We previously observed in murine experimental BAI that S. epidermidis persists in peri-implant tissue rather than on the implanted biomaterial itself (Boelens et al., J Infect Dis 2000;181:1337-1349; Broekhuizen et al., Infect Immun 2007;75:1129-1136). To investigate the efficacy of rifampicin/vancomycin to clear S. epidermidis from implants and peri-implant tissues, mice with… CONTINUE READING
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