Staphylococcus epidermidis biofilms with higher proportions of dormant bacteria induce a lower activation of murine macrophages.

@article{Cerca2011StaphylococcusEB,
  title={Staphylococcus epidermidis biofilms with higher proportions of dormant bacteria induce a lower activation of murine macrophages.},
  author={Filipe Cerca and Filipa A. Andrade and {\^A}ngela França and Elva Bonif{\'a}cio Andrade and Ad{\'i}lia Ribeiro and Agostinho A. Almeida and Nuno Cerca and Gerald B Pier and Joana Azeredo and Manuel Vilanova},
  journal={Journal of medical microbiology},
  year={2011},
  volume={60 Pt 12},
  pages={1717-24}
}
Staphylococcus epidermidis is an opportunistic pathogen and, due to its ability to establish biofilms, is a leading causative agent of indwelling medical device-associated infection. The presence of high amounts of dormant bacteria is a hallmark of biofilms, making them more tolerant to antimicrobials and to the host immune response. We observed that S. epidermidis biofilms grown in excess glucose accumulated high amounts of viable but non-culturable (VBNC) bacteria, as assessed by their low… CONTINUE READING
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