Staphylococcus aureus supernatant induces the release of mouse β-defensin-14 from osteoblasts via the p38 MAPK and NF-κB pathways.

@article{Zhu2013StaphylococcusAS,
  title={Staphylococcus aureus supernatant induces the release of mouse β-defensin-14 from osteoblasts via the p38 MAPK and NF-κB pathways.},
  author={Chen Zhu and Hui Qin and Tao Cheng and Hong-lue Tan and Yong-yuan Guo and Si-Feng Shi and De-sheng Chen and Xian-long Zhang},
  journal={International journal of molecular medicine},
  year={2013},
  volume={31 6},
  pages={
          1484-94
        }
}
Mammalian β-defensins are small cationic peptides of approximately 2-6 kDa that have been implicated in mediating innate immune defenses against microbial infection. Previous studies have reported that mouse β-defensin-14 (MBD‑14), based on structural and functional similarities, appears to be an ortholog of human β-defensin-3 (HBD-3). The aim of this study was to identify the signaling pathways that contribute to the expression of MBD-14 in mouse osteoblasts (OBs) upon contact with methicillin… CONTINUE READING

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