Staphylococcus aureus subverts cutaneous defense by D-alanylation of teichoic acids.

@article{Simanski2013StaphylococcusAS,
  title={Staphylococcus aureus subverts cutaneous defense by D-alanylation of teichoic acids.},
  author={Maren Simanski and Regine Glaeser and Bente K{\"o}ten and Ulf Meyer-Hoffert and Stefanie Wanner and Christopher Weidenmaier and Andreas Peschel and J{\"u}rgen Harder},
  journal={Experimental dermatology},
  year={2013},
  volume={22 4},
  pages={294-6}
}
The Gram-positive bacterium Staphylococcus aureus is a frequent skin colonizer that often causes severe skin infections. It has been reported that neutralizing the negatively charged bacterial surface through the incorporation of d-alanine in its teichoic acids confers reduced susceptibility of S. aureus towards cationic antimicrobial peptides (AMPs). Using a S. aureus strain deficient in d-alanylated teichoic acids (dltA mutant), we demonstrate that d-alanylation of its surface reduces the… CONTINUE READING

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