Staphylococcus aureus protein A triggers T cell-independent B cell proliferation by sensitizing B cells for TLR2 ligands.

@article{BekeredjianDing2007StaphylococcusAP,
  title={Staphylococcus aureus protein A triggers T cell-independent B cell proliferation by sensitizing B cells for TLR2 ligands.},
  author={Isabelle Bekeredjian-Ding and Seiichi Inamura and Thomas Giese and Hermann Moll and Stefan Endres and A Shum Cheong Sing and Ulrich Zaehringer and Gunther Hartmann},
  journal={Journal of immunology},
  year={2007},
  volume={178 5},
  pages={2803-12}
}
UNLABELLED B cells possess functional characteristics of innate immune cells, as they can present Ag to T cells and can be stimulated with microbial molecules such as TLR ligands. Because crude preparations of Staphylococcus aureus are frequently used as polyclonal B cell activators and contain potent TLR2 activity, the scope of this study was to analyze the impact of S. aureus-derived TLR2-active substances on human B cell activation. Peripheral B cells stimulated with chemically modified S… CONTINUE READING