Staphylococcus aureus leukotoxin GH promotes formation of neutrophil extracellular traps.

@article{Malachowa2013StaphylococcusAL,
  title={Staphylococcus aureus leukotoxin GH promotes formation of neutrophil extracellular traps.},
  author={Natalia Malachowa and Scott D. Kobayashi and Brett Freedman and David W T Dorward and Frank R Deleo},
  journal={Journal of immunology},
  year={2013},
  volume={191 12},
  pages={6022-9}
}
Staphylococcus aureus secretes numerous virulence factors that facilitate evasion of the host immune system. Among these molecules are pore-forming cytolytic toxins, including Panton-Valentine leukocidin (PVL), leukotoxin GH (LukGH; also known as LukAB), leukotoxin DE, and γ-hemolysin. PVL and LukGH have potent cytolytic activity in vitro, and both toxins are proinflammatory in vivo. Although progress has been made toward elucidating the role of these toxins in S. aureus virulence, our… CONTINUE READING