Staphylococcus aureus isolates from chronic osteomyelitis are characterized by high host cell invasion and intracellular adaptation, but still induce inflammation.

@article{Kalinka2014StaphylococcusAI,
  title={Staphylococcus aureus isolates from chronic osteomyelitis are characterized by high host cell invasion and intracellular adaptation, but still induce inflammation.},
  author={Julia Kalinka and Marie Hachmeister and Jennifer Geraci and Daniel O. Sordelli and Uwe Hansen and Silke Niemann and Sylvia Oetermann and Georg Peters and Bettina Loeffler and Lorena Tuchscherr},
  journal={International journal of medical microbiology : IJMM},
  year={2014},
  volume={304 8},
  pages={1038-49}
}
Osteomyelitis is a severe inflammatory disease of the bone that is mainly caused by Staphylococcus aureus. Particularly, bone infections are difficult to treat and can develop into a chronic course with a high relapsing rate despite of antimicrobial treatments. The complex interaction of staphylococci with osseous tissue and the bacterial ability to invade host cells are thought to determine the severity of infection. Yet, defined bacterial virulence factors responsible for the pathogenesis of… CONTINUE READING
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