Staphylococcus aureus induces expression of receptor activator of NF-kappaB ligand and prostaglandin E2 in infected murine osteoblasts.

@article{Somayaji2008StaphylococcusAI,
  title={Staphylococcus aureus induces expression of receptor activator of NF-kappaB ligand and prostaglandin E2 in infected murine osteoblasts.},
  author={Shankari N Somayaji and Samantha Ritchie and Mahnaz Sahraei and Ian Marriott and Michael C. Hudson},
  journal={Infection and immunity},
  year={2008},
  volume={76 11},
  pages={5120-6}
}
Osteomyelitis is an inflammatory disease of the bone that is characterized by the presence of necrotic bone tissue and increased osteoclast activity. Staphylococcus aureus is responsible for approximately 80% of all cases of human osteomyelitis. While the disease is especially difficult to treat, the pathogenesis of S. aureus-induced osteomyelitis is poorly understood. Elucidating the molecular mechanisms by which S. aureus induces osteomyelitis could lead to a better understanding of the… CONTINUE READING