Staphylococcus aureus golden pigment impairs neutrophil killing and promotes virulence through its antioxidant activity

@article{Liu2005StaphylococcusAG,
  title={Staphylococcus aureus golden pigment impairs neutrophil killing and promotes virulence through its antioxidant activity},
  author={George Y. Liu and Anthony Essex and John T. Buchanan and Vivekanand Datta and Hal M. Hoffman and John F. Bastian and Joshua Fierer and Victor Nizet},
  journal={The Journal of Experimental Medicine},
  year={2005},
  volume={202},
  pages={209 - 215}
}
Golden color imparted by carotenoid pigments is the eponymous feature of the human pathogen Staphylococcus aureus. Here we demonstrate a role of this hallmark phenotype in virulence. Compared with the wild-type (WT) bacterium, a S. aureus mutant with disrupted carotenoid biosynthesis is more susceptible to oxidant killing, has impaired neutrophil survival, and is less pathogenic in a mouse subcutaneous abscess model. The survival advantage of WT S. aureus over the carotenoid-deficient mutant is… CONTINUE READING
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