Staphylococcus aureus genetic loci impacting growth and survival in multiple infection environments.

@article{Coulter1998StaphylococcusAG,
  title={Staphylococcus aureus genetic loci impacting growth and survival in multiple infection environments.},
  author={Silvija N. Coulter and William R Schwan and Eva Y. W. Ng and Michael H. Langhorne and Heather D. Ritchie and S. Westbrock-Wadman and W. O. Hufnagle and Kim R. Folger and Arnold S. Bayer and C. K. Stover},
  journal={Molecular microbiology},
  year={1998},
  volume={30 2},
  pages={393-404}
}
The Gram-positive bacterium Staphylococcus aureus infects diverse tissues and causes a wide spectrum of diseases, suggesting that it possesses a repertoire of distinct molecular mechanisms promoting bacterial survival in disparate in vivo environments. Signature-tag transposon mutagenesis screening of a 1520-member library identified numerous S. aureus genetic loci affecting growth and survival in four complementary animal infection models including mouse abscess, bacteraemia and wound and… CONTINUE READING