Staphylococcus aureus evades lysozyme-based peptidoglycan digestion that links phagocytosis, inflammasome activation, and IL-1beta secretion.

@article{Shimada2010StaphylococcusAE,
  title={Staphylococcus aureus evades lysozyme-based peptidoglycan digestion that links phagocytosis, inflammasome activation, and IL-1beta secretion.},
  author={Takahiro Shimada and Bong Goo Park and Andrea J. Wolf and Constantinos Brikos and Helen S. Goodridge and Courtney A Becker and Christopher N. Reyes and Edward A Miao and Alan Aderem and Friedrich G{\"o}tz and George Y. Liu and David M Underhill},
  journal={Cell host & microbe},
  year={2010},
  volume={7 1},
  pages={38-49}
}
IL-1beta produced by phagocytes is important for protection against the mucosal pathogen Staphylococcus aureus. Processing and maturation of this cytokine requires activation of the multiprotein inflammasome complex. We observed that the bacterial cell wall component peptidoglycan (PGN) must be particulate and internalized via phagocytosis to activate NLRP3 inflammasomes and IL-1beta secretion. In the context of S. aureus infection of macrophages, we find that phagocytosis and lysozyme-based… CONTINUE READING

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