Staphylococcus aureus-derived membrane vesicles exacerbate skin inflammation in atopic dermatitis.

@article{Jun2017StaphylococcusAM,
  title={Staphylococcus aureus-derived membrane vesicles exacerbate skin inflammation in atopic dermatitis.},
  author={So Hyun Jun and J H Lee and Seung Il Kim and C W Choi and T I Park and Hyera Jung and J W Cho and S Kim and Jong-Min Lee},
  journal={Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology},
  year={2017},
  volume={47 1},
  pages={
          85-96
        }
}
BACKGROUND Skin colonization or infection with Staphylococcus aureus is known to trigger aggravation of atopic dermatitis (AD). However, the exact mechanisms by which S. aureus can worsen AD are unknown. OBJECTIVE We investigated whether and how S. aureus-derived membrane vesicles (MVs) contribute to worsening of AD. METHODS Immunohistochemical and immunoelectron microscopic analyses were performed to detect staphylococcal protein A (SPA) in the epidermis of AD lesions. HaCaT cells were… CONTINUE READING
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