Staphylococcus aureus-derived factors induce IL-10, IFN-γ and IL-17A-expressing FOXP3+CD161+ T-helper cells in a partly monocyte-dependent manner.

@article{Bjrkander2016StaphylococcusAF,
  title={Staphylococcus aureus-derived factors induce IL-10, IFN-γ and IL-17A-expressing FOXP3+CD161+ T-helper cells in a partly monocyte-dependent manner.},
  author={Sophia Bj{\"o}rkander and Lena Hell and Maria A. Johansson and Manuel Mata Forsberg and Gintare Lasaviciute and Stefan Roos and Ulrika Holmlund and Eva Sverremark-Ekstr{\"o}m},
  journal={Scientific reports},
  year={2016},
  volume={6},
  pages={22083}
}
Staphylococcus aureus (S. aureus) is a human pathogen as well as a frequent colonizer of skin and mucosa. This bacterium potently activates conventional T-cells through superantigens and it is suggested to induce T-cell cytokine-production as well as to promote a regulatory phenotype in T-cells in order to avoid clearance. This study aimed to investigate how S. aureus impacts the production of regulatory and pro-inflammatory cytokines and the expression of CD161 and HELIOS by peripheral CD4… CONTINUE READING
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