Staphylococcus aureus degrades neutrophil extracellular traps to promote immune cell death.

@article{Thammavongsa2013StaphylococcusAD,
  title={Staphylococcus aureus degrades neutrophil extracellular traps to promote immune cell death.},
  author={Vilasack Thammavongsa and Dominique Missiakas and Olaf Schneewind},
  journal={Science},
  year={2013},
  volume={342 6160},
  pages={863-6}
}
Bacterial invasion of host tissues triggers polymorphonuclear leukocytes to release DNA [neutrophil extracellular traps (NETs)], thereby immobilizing microbes for subsequent clearance by innate defenses including macrophage phagocytosis. We report here that Staphylococcus aureus escapes these defenses by converting NETs to deoxyadenosine, which triggers the caspase-3-mediated death of immune cells. Conversion of NETs to deoxyadenosine requires two enzymes, nuclease and adenosine synthase, that… CONTINUE READING
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We thank J

N. Niitsu, Y. Yamaguchi, +3 authors 3368–3375 . Acknowledgments
D. Sauer for macrophages. This work was supported by grants from the National Institute of Allergy and Infectious Diseases (AI038897, AI052474, and AI057153) and the American Heart Association

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