Staphylococcus aureus degrades neutrophil extracellular traps to promote immune cell death.

  title={Staphylococcus aureus degrades neutrophil extracellular traps to promote immune cell death.},
  author={Vilasack Thammavongsa and Dominique Missiakas and Olaf Schneewind},
  volume={342 6160},
Bacterial invasion of host tissues triggers polymorphonuclear leukocytes to release DNA [neutrophil extracellular traps (NETs)], thereby immobilizing microbes for subsequent clearance by innate defenses including macrophage phagocytosis. We report here that Staphylococcus aureus escapes these defenses by converting NETs to deoxyadenosine, which triggers the caspase-3-mediated death of immune cells. Conversion of NETs to deoxyadenosine requires two enzymes, nuclease and adenosine synthase, that… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 23 times. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 77 extracted citations


Publications referenced by this paper.

We thank J

N. Niitsu, Y. Yamaguchi, +3 authors 3368–3375 . Acknowledgments
D. Sauer for macrophages. This work was supported by grants from the National Institute of Allergy and Infectious Diseases (AI038897, AI052474, and AI057153) and the American Heart Association

Similar Papers

Loading similar papers…