Staphylococcus aureus beta-toxin induces lung injury through syndecan-1.

  title={Staphylococcus aureus beta-toxin induces lung injury through syndecan-1.},
  author={Atsuko Hayashida and Allison Humes Bartlett and T. J. Foster and Pyong Woo Park},
  journal={The American journal of pathology},
  volume={174 2},
In pneumonia caused by the bacterium Staphylococcus aureus, the intense inflammatory response that is triggered by this infection can lead to the development of lung injury. Little is known, however, about the impact of specific virulence factors on this inflammatory disorder, which causes both significant mortality and morbidity. In this study, we examined the role of beta-toxin, a neutral sphingomyelinase, in S. aureus-induced lung injury. Our results showed that the central features of lung… CONTINUE READING
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