Staphylococcus aureus alpha-toxin induces apoptosis in endothelial cells.

  title={Staphylococcus aureus alpha-toxin induces apoptosis in endothelial cells.},
  author={Barbara E Menzies and I Kourteva},
  journal={FEMS immunology and medical microbiology},
  volume={29 1},
The internalization of Staphylococcus aureus by cultured human umbilical vein endothelial cells was recently shown to induce apoptosis. We examined the role of alpha-toxin, a major pore-forming toxin secreted by S. aureus, in causing apoptosis in vitro. Purified alpha-toxin, at sublytic concentrations, induced apoptosis in endothelial cell monolayers. Comparisons of two alpha-toxin (hla)-positive S. aureus strains and their isogenic hla-deficient mutants in the invasion assay of endothelial… CONTINUE READING

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