Staphylococcus aureus Manganese Transport Protein C Is a Highly Conserved Cell Surface Protein That Elicits Protective Immunity Against S. aureus and Staphylococcus epidermidis

@inproceedings{Anderson2012StaphylococcusAM,
  title={Staphylococcus aureus Manganese Transport Protein C Is a Highly Conserved Cell Surface Protein That Elicits Protective Immunity Against S. aureus and Staphylococcus epidermidis},
  author={Annaliesa S. Anderson and Ingrid Lea Scully and Yekaterina Timofeyeva and Ellen Murphy and Lisa K Mcneil and Terri L Mininni and Lorna Nu{\~n}ez and Marjolaine B Carri{\`e}re and Christine Lee Singer and Deborah A. Dilts and Kathrin Ute Jansen},
  booktitle={The Journal of infectious diseases},
  year={2012}
}
Staphylococcus aureus and other staphylococci cause severe human disease, and there are currently no vaccines available. We evaluated whether manganese transport protein C (MntC), which is conserved across the staphylococcal species group, could confer protection against S. aureus and Staphylococcus epidermidis. In vivo analysis of S. aureus MntC expression revealed that expression occurs very early during the infectious cycle. Active immunization with MntC was effective at reducing the… CONTINUE READING

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