Staphylococcal manipulation of host immune responses

  title={Staphylococcal manipulation of host immune responses},
  author={Vilasack Thammavongsa and Hwan Keun Kim and Dominique Missiakas and Olaf Schneewind},
  journal={Nature Reviews Microbiology},
Staphylococcus aureus, a bacterial commensal of the human nares and skin, is a frequent cause of soft tissue and bloodstream infections. A hallmark of staphylococcal infections is their frequent recurrence, even when treated with antibiotics and surgical intervention, which demonstrates the bacterium's ability to manipulate innate and adaptive immune responses. In this Review, we highlight how S. aureus virulence factors inhibit complement activation, block and destroy phagocytic cells and… CONTINUE READING
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