Staphylococcal enterotoxin D is a promiscuous superantigen offering multiple modes of interactions with the MHC class II receptors.

@article{AlDaccak1998StaphylococcalED,
  title={Staphylococcal enterotoxin D is a promiscuous superantigen offering multiple modes of interactions with the MHC class II receptors.},
  author={Reem Al-Daccak and Khalil Mehindate and Farida Damdoumi and Pierre Etongu{\'e}-Mayer and Helen B Nilsson and Per Antonsson and Michael Sundstr{\"o}m and Mikael Dohlsten and Rafick Pierre S{\'e}kaly and Walid M Mourad},
  journal={Journal of immunology},
  year={1998},
  volume={160 1},
  pages={225-32}
}
Dimerization of MHC class II molecules on the cell surface of human THP-1 monocytic cell line is a requirement for staphylococcal superantigen (SAG)-induced cytokine gene expression. The capacities of various SAG to induce this response are governed by their modes of interaction with MHC class II molecules. Staphylococcal enterotoxin A (SEA), with its two binding sites, dimerizes MHC class II molecules and subsequently induces cytokine gene expression in THP-1 cells. Here, we demonstrate that… CONTINUE READING

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