Staphopains modulate Staphylococcus aureus biofilm integrity.

  title={Staphopains modulate Staphylococcus aureus biofilm integrity.},
  author={Joe Michael Mootz and Cheryl Malone and Lindsey N Shaw and Alexander R. Horswill},
  journal={Infection and immunity},
  volume={81 9},
Staphylococcus aureus is a known cause of chronic biofilm infections that can reside on medical implants or host tissue. Recent studies have demonstrated an important role for proteinaceous material in the biofilm structure. The S. aureus genome encodes many secreted proteases, and there is growing evidence that these enzymes have self-cleavage properties that alter biofilm integrity. However, the specific contribution of each protease and mechanism of biofilm modulation is not clear. To… CONTINUE READING


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