Stanniocalcin-2 inhibits mammalian growth by proteolytic inhibition of the insulin-like growth factor axis.

@article{Jepsen2015Stanniocalcin2IM,
  title={Stanniocalcin-2 inhibits mammalian growth by proteolytic inhibition of the insulin-like growth factor axis.},
  author={Malene R Jepsen and S{\o}ren Kl{\o}verpris and Jakob H. Mikkelsen and Josefine H Pedersen and Ernst-Martin F{\"u}chtbauer and Lisbeth S Laursen and Claus Oxvig},
  journal={The Journal of biological chemistry},
  year={2015},
  volume={290 6},
  pages={
          3430-9
        }
}
Mammalian stanniocalcin-2 (STC2) is a secreted polypeptide widely expressed in developing and adult tissues. However, although transgenic expression in mice is known to cause severe dwarfism, and targeted deletion of STC2 causes increased postnatal growth, its precise biological role is still unknown. We found that STC2 potently inhibits the proteolytic activity of the growth-promoting metalloproteinase, pregnancy-associated plasma protein-A (PAPP-A). Proteolytic inhibition requires covalent… CONTINUE READING

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