Standing and Supine Blood Pressure Outcomes Associated With Droxidopa and Midodrine in Patients With Neurogenic Orthostatic Hypotension: A Bayesian Meta-analysis and Mixed Treatment Comparison of Randomized Trials

@article{Chen2018StandingAS,
  title={Standing and Supine Blood Pressure Outcomes Associated With Droxidopa and Midodrine in Patients With Neurogenic Orthostatic Hypotension: A Bayesian Meta-analysis and Mixed Treatment Comparison of Randomized Trials},
  author={Jack J. Chen and Yi Han and Jonathan Tang and Iv{\'a}n Burgos Portillo and Robert A. Hauser and Khashayar Dashtipour},
  journal={Annals of Pharmacotherapy},
  year={2018},
  volume={52},
  pages={1182 - 1194}
}
Background: The comparative effects of droxidopa and midodrine on standing systolic blood pressure (sSBP) and risk of supine hypertension in patients with neurogenic orthostatic hypotension (NOH) are unknown. Objective: To perform a Bayesian mixed-treatment comparison meta-analysis of droxidopa and midodrine in the treatment of NOH. Methods: The PubMed, CENTRAL, and EMBASE databases were searched up to November 16, 2016. Study selection consisted of randomized trials comparing droxidopa or… 
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Management Strategies for Comorbid Supine Hypertension in Patients with Neurogenic Orthostatic Hypotension

The pathophysiology and clinical characteristics of neurogenic orthostatic hypotension and neurogenic supine hypertension are reviewed, and a stepwise treatment approach is presented to help guide neurologists in managing patients with both nOH and nSH.

Cardiovascular Safety Considerations in the Treatment of Neurogenic Orthostatic Hypotension.

Droxidopa for the treatment of neurogenic orthostatic hypotension in neurodegenerative diseases

The authors review the effects of droxidopa in NOH with a focus on the neurodegenerative diseases PD, MSA, and pure autonomic failure (PAF, where results appear essentially similar) and indicates a positive yet short-lasting effect of the drug on OH Questionnaire composite score, light-headedness/dizziness score, and standing BP during the first two treatment-weeks.

Orthostatic Hypotension in Hypertensive Adults: Harry Goldblatt Award for Early Career Investigators 2021

Recent evidence suggests that intensive blood pressure control may reduce the risk of orthostatic hypotension, and a detailed characterization of blood pressure variability is essential to tailoring a treatment plan and can be accomplished using both in-office and out-of-office monitoring.

Orthostatic Hypotension in Older Adults

It is concluded that orthostatic hypotension is common in the elderly and increases with advancing age, and is associated with cardiovascular disease, particularly those manifestations measured objectively, such as carotid stenosis.

Role of nurses and nurse practitioners in the recognition, diagnosis, and management of neurogenic orthostatic hypotension: a narrative review

Neurogenic orthostatic hypotension (nOH) is a sustained reduction in blood pressure (BP) upon standing that is caused by autonomic dysfunction and is common among patients with a variety of…

Neurogenic Orthostatic Hypotension in Parkinson Disease: A Primer

The pathophysiology and effects of Neurogenic orthostatic hypotension, a potentially serious manifestation of cardiovascular sympathetic failure that occurs in approximately 30% of patients with PD, are reviewed.

Neurogenic orthostatic hypotension with Parkinson's disease as a cause of syncope: A case report

Ambulatory blood pressure monitoring is a cost-effective method for its diagnosis, and non-pharmacological measures are still the primary management methods for syncope.

New horizons in the ageing autonomic nervous system: orthostatic hypotension and supine hypertension

The healthy barore Flex, and physiological and pathophysiological reasons for impaired baroreflex function in older people, are discussed, and strategies for balancing these conflicting priorities are discussed.

Orthostatic hypotension in older people: considerations, diagnosis and management.

In summary, orthostatic hypotension (and associated supine hypertension) are common, dangerous and disabling, but adherence to simple structures management strategies can result in major improvements.

References

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