Standing Genetic Variation and the Evolution of Drug Resistance in HIV

  title={Standing Genetic Variation and the Evolution of Drug Resistance in HIV},
  author={Pleuni Simone Pennings},
  booktitle={PLoS Computational Biology},
Drug resistance remains a major problem for the treatment of HIV. Resistance can occur due to mutations that were present before treatment starts or due to mutations that occur during treatment. The relative importance of these two sources is unknown. Resistance can also be transmitted between patients, but this process is not considered in the current study. We study three different situations in which HIV drug resistance may evolve: starting triple-drug therapy, treatment with a single dose… CONTINUE READING
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