Standardized use of novel oral anticoagulants plasma level thresholds in a new thrombolysis decision making protocol

@article{Kepplinger2015StandardizedUO,
  title={Standardized use of novel oral anticoagulants plasma level thresholds in a new thrombolysis decision making protocol},
  author={Jessica Kepplinger and Alexandra Prakapenia and Kristian Barlinn and Gabriele Siegert and Siegmund Gehrisch and Charlotte Zerna and Jan Beyer-Westendorf and Volker Puetz and Heinz Reichmann and Timo Siepmann and Ulf Bodechtel},
  journal={Journal of Thrombosis and Thrombolysis},
  year={2015},
  volume={41},
  pages={293-300}
}
Acute ischemic stroke (AIS) patients receiving non-vitamin-K antagonist oral anticoagulants (NOAC) are commonly excluded from thrombolytic therapy, as interpretation of coagulation tests remains unclear. We aimed to investigate the applicability of a novel institutional protocol for thrombolysis based on current expert recommendations and NOAC specific coagulation assessment. We included hospitalized AIS patients receiving NOAC for at least 24 h and consecutive AIS patients not receiving NOAC… CONTINUE READING

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