Standardized analysis of mandibular osteoradionecrosis in a rat model.

@article{Tamplen2011StandardizedAO,
  title={Standardized analysis of mandibular osteoradionecrosis in a rat model.},
  author={Matthew Tamplen and Kelley Trapp and Ichiro Nishimura and Bob B Armin and Michael L. Steinberg and J. Beumer and Elliot Abemayor and Vishad Nabili},
  journal={Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery},
  year={2011},
  volume={145 3},
  pages={404-10}
}
OBJECTIVE To develop a rat model of mandibular osteoradionecrosis(ORN) that uses novel micro-computed tomography bone volume analysis and detailed histology to provide a more effective, quantifiable, and standardized way to study ORN in vivo. STUDY DESIGN Animal model. SETTING Academic medical center. SUBJECTS AND METHODS Modifications to our previously published rat model of mandibular ORN were done to develop an ideal protocol consisting of 10 rats (6 experimental and 4 controls) with… CONTINUE READING
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