Standardized Aqueous Tribulus terristris (nerunjil) extract attenuates hyperalgesia in experimentally induced diabetic neuropathic pain model: role of oxidative stress and inflammatory mediators.

@article{Ranjithkumar2013StandardizedAT,
  title={Standardized Aqueous Tribulus terristris (nerunjil) extract attenuates hyperalgesia in experimentally induced diabetic neuropathic pain model: role of oxidative stress and inflammatory mediators.},
  author={Ravichandran Ranjithkumar and S Prathab Balaji and Bhaskar Balaji and Ramanujam Ramesh and Muthiah Ramanathan},
  journal={Phytotherapy research : PTR},
  year={2013},
  volume={27 11},
  pages={
          1646-57
        }
}
The present study aimed to evaluate standardized aqueous Tribulus terristris (nerunjil) extract on the pain threshold response in streptozotocin (STZ)-induced diabetic neuropathic pain model in rats. After a single injection of STZ (40 mg/kg; i.p.), Wistar male rats were tested by the thermal and chemical-induced pain models. Diabetic rats exhibited significant hyperalgesia, and these rats were left untreated for the first four weeks. Thereafter, treatment was initiated and continued up to week… CONTINUE READING
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