Standardization of flow cytometric minimal residual disease evaluation in acute lymphoblastic leukemia: Multicentric assessment is feasible.

@article{Dworzak2008StandardizationOF,
  title={Standardization of flow cytometric minimal residual disease evaluation in acute lymphoblastic leukemia: Multicentric assessment is feasible.},
  author={Michael Dworzak and Giuseppe Gaipa and Richard Ratei and Marinella Veltroni and Angela Schumich and Oscar Maglia and Leonid Karawajew and Allessandra Benetello and Ulrike Poetschger and Zvenyslava Husak and Helmut Gadner and Andrea Biondi and W G Ludwig and Giuseppe Basso},
  journal={Cytometry. Part B, Clinical cytometry},
  year={2008},
  volume={74 6},
  pages={331-40}
}
BACKGROUND Single-laboratory experience showed that flow cytometric (FCM) assessment of minimal residual disease (MRD) in acute lymphoblastic leukemia (ALL) is feasible in most patients and gives independent prognostic information. It is, however, not known whether FCM analysis can reliably be standardized for multicentric application. METHODS An extensive standardization program was installed in four collaborating laboratories, which study FCM-MRD in children treated with the AIEOP-BFM-ALL… CONTINUE READING

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