Standardization of estrogen receptor measurement in breast cancer suggests false-negative results are a function of threshold intensity rather than percentage of positive cells.

@article{Welsh2011StandardizationOE,
  title={Standardization of estrogen receptor measurement in breast cancer suggests false-negative results are a function of threshold intensity rather than percentage of positive cells.},
  author={Allison W. Welsh and Christopher B. Moeder and Sudha Kumar and Peter Gershkovich and Elaine T. Alarid and Malini Harigopal and Bruce G. Haffty and David L. Rimm},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2011},
  volume={29 22},
  pages={
          2978-84
        }
}
PURPOSE Recent misclassification (false negative) incidents have raised awareness concerning limitations of immunohistochemistry (IHC) in assessment of estrogen receptor (ER) in breast cancer. Here we define a new method for standardization of ER measurement and then examine both change in percentage and threshold of intensity (immunoreactivity) to assess sources for test discordance. METHODS An assay was developed to quantify ER by using a control tissue microarray (TMA) and a series of cell… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 41 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 19 REFERENCES

Bad cancer tests draw scrutiny

  • A Matthews
  • Wall Street Journal, January
  • 2008
1 Excerpt

Similar Papers

Loading similar papers…