Standardization of HER2 testing: results of an international proficiency-testing ring study

@article{Dowsett2007StandardizationOH,
  title={Standardization of HER2 testing: results of an international proficiency-testing ring study},
  author={Mitch Dowsett and W. Mark Hanna and Mark Kockx and Fr{\'e}d{\'e}rique Penault-Llorca and Josef Rueschoff and Thorsten Gutjahr and Kai Habben and Marc J. van de Vijver},
  journal={Modern Pathology},
  year={2007},
  volume={20},
  pages={584-591}
}
Human epidermal growth factor receptor 2 (HER2) positivity in breast cancer is a prognostic factor regarding tumor aggressiveness and a predictive factor for response to trastuzumab (Herceptin®). Early and accurate HER2 testing of all breast cancer patients at primary diagnosis is essential for optimal disease management. Routine HER2 tests, such as immunohistochemistry and fluorescence in situ hybridization (FISH), are subject to interlaboratory variation, and validation by laboratory… CONTINUE READING
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