Standard versus high-dose CVVHDF for ICU-related acute renal failure.

  title={Standard versus high-dose CVVHDF for ICU-related acute renal failure.},
  author={Ashita J Tolwani and Ruth C. Campbell and Brenda S Stofan and Katherine Robin Lai and Robert H. Oster and Keith M. Wille},
  journal={Journal of the American Society of Nephrology : JASN},
  volume={19 6},
The effect of dosage of continuous venovenous hemodiafiltration (CVVHDF) on survival in patients with acute renal failure (ARF) is unknown. In this study, 200 critically ill patients with ARF were randomly assigned to receive CVVHDF with prefilter replacement fluid at an effluent rate of either 35 ml/kg per h (high dosage) or 20 ml/kg per h (standard dosage). The primary study outcome, survival to the earlier of either intensive care unit discharge or 30 d, was 49% in the high-dosage arm and 56… CONTINUE READING
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