Standard dosing of amikacin and gentamicin in critically ill patients results in variable and subtherapeutic concentrations.

@article{Roger2015StandardDO,
  title={Standard dosing of amikacin and gentamicin in critically ill patients results in variable and subtherapeutic concentrations.},
  author={Claire Marie Roger and Bastian Nucci and Nicolas Molinari and Sophie Bastide and Gilbert Saissi and Gael Pradel and Saber David Barbar and Cl{\'e}ment Aubert and Sophie Lloret and Loubna Elotmani and Anne Polge and J Y Lefrant and Jason A. Roberts and Laurent Muller},
  journal={International journal of antimicrobial agents},
  year={2015},
  volume={46 1},
  pages={21-7}
}
Low peak plasma concentrations (Cmax) of amikacin and gentamicin are reported in intensive care unit (ICU) patients after administration of the first dose. The present study aimed to describe the proportion of ICU patients in whom an adequate Cmax was achieved throughout the course of therapy. Septic ICU patients with an indication for intravenous amikacin or gentamicin were eligible for inclusion in this single-centre observational study. The first and subsequent doses and the corresponding… CONTINUE READING
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Bon usage des aminosides administrés par voie injectable : gentamicine , tobramycine , nétilmicine , amikacine — Mise au point

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