Stalking influenza by vaccination with pre-fusion headless HA mini-stem

@inproceedings{Valkenburg2016StalkingIB,
  title={Stalking influenza by vaccination with pre-fusion headless HA mini-stem},
  author={Sophie A. Valkenburg and Vamsee V. Aditya Mallajosyula and Olive Tin-Wai Li and Alex W. H. Chin and George William Carnell and Nigel J Temperton and Raghavan Varadarajan and Leo L. M. Poon},
  booktitle={Scientific reports},
  year={2016}
}
Inaccuracies in prediction of circulating viral strain genotypes and the possibility of novel reassortants causing a pandemic outbreak necessitate the development of an anti-influenza vaccine with increased breadth of protection and potential for rapid production and deployment. The hemagglutinin (HA) stem is a promising target for universal influenza vaccine as stem-specific antibodies have the potential to be broadly cross-reactive towards different HA subtypes. Here, we report the design of… CONTINUE READING
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