Stalk cell phenotype depends on integration of Notch and Smad1/5 signaling cascades.

@article{Moya2012StalkCP,
  title={Stalk cell phenotype depends on integration of Notch and Smad1/5 signaling cascades.},
  author={Iv{\'a}n M Moya and Lieve Umans and Elke Maas and Paulo N. G. Pereira and Karen Beets and Annick Francis and Ward Sents and Elizabeth J Robertson and Christine L Mummery and Danny Huylebroeck and An Zwijsen},
  journal={Developmental cell},
  year={2012},
  volume={22 3},
  pages={
          501-14
        }
}
Gradients of vascular endothelial growth factor (VEGF) induce single endothelial cells to become leading tip cells of emerging angiogenic sprouts. Tip cells then suppress tip-cell features in adjacent stalk cells via Dll4/Notch-mediated lateral inhibition. We report here that Smad1/Smad5-mediated BMP signaling synergizes with Notch signaling during selection of tip and stalk cells. Endothelium-specific inactivation of Smad1/Smad5 in mouse embryos results in impaired Dll4/Notch signaling and… CONTINUE READING

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