Staining of glial fibrillary acidic protein (GFAP) in lumbar spinal cord increases following a sciatic nerve constriction injury

  title={Staining of glial fibrillary acidic protein (GFAP) in lumbar spinal cord increases following a sciatic nerve constriction injury},
  author={Christopher J. Garrison and Patrick M. Dougherty and Keith C. Kajander and Susan M. Carlton},
  journal={Brain Research},
A quantitative analysis of the glial cell reaction in primary sensory termination areas following sciatic nerve injury and treatment with nerve growth factor in the adult rat
The results show that the astroglial cell response in the nucleus gracilis and the spinal cord dorsal horn is rapid in comparison with previously described central degenerative changes following peripheral nerve lesions (transganglionic degeneration), and that the „signal” from the axotomized neurons which induces these reactions can not be prevented by exogenous NGF applied to the peripheral nerve.
Partial peripheral nerve injury leads to activation of astroglia and microglia which parallels the development of allodynic behavior
It is demonstrated that microglia and astroglia are activated following PSNL and that their increase in IR correlates with the development of allodynic behavior.
Differential astroglial responses in the spinal cord of rats submitted to a sciatic nerve double crush treated with local injection of cultured Schwann cell suspension or lesioned spinal cord extract: implications on cell therapy for nerve repair.
Spinal cord astrocytes react according to repair processes of axotomized nerve, which may influence the functional outcome and should be considered during the neurosurgery strategies.
Astrogliosis in different zones of the spinal cord gray matter after sciatic nerve axotomy in the newborn rat: a morphometric and immunohistochemical study.
There may be an initial post-axotomic proliferative phase of the glial cells, which was followed by a differentiation phase following unilateral sciatic nerve axotomy, the conclusion of the study is.
Sequential alteration of microglia and astrocytes in the rat thalamus following spinal nerve ligation
The results demonstrate a sequential alteration of microglia and astrocytes in the thalamus of animals with lesioned peripheral nerves, and report unprecedented concomitant molecular signs ofMicroglial activation and morphological signs ofmicroglial decline in theThalamic nuclei of these animals.
Differential Changes in Neuronal Excitability in the Spinal Dorsal Horn After Spinal Nerve Ligation in Rats
It is concluded that nerve injury causes differential changes in neuronal excitability in the spinal dorsal horn, which may coincide with glial activation, and these changes may play a substantial role in the pathogenesis of neuropathic pain after peripheral nerve injury.


Increased glial fibrillary acidic protein synthesis in astrocytes during retrograde reaction of the rat facial nucleus
The increase in the astrocytic GFAP synthesis seems to be the earliest glial response to retrograde changes in facial motoneurons.
Deafferentation‐induced alterations in the rat dorsal horn: I. Comparison of peripheral nerve injury vs. rhizotomy effects on presynaptic, postsynaptic, and Glial processes
Results confirm past descriptions of pre‐ and postsynaptic changes resulting from peripheral nerve section, but newly reveal that dendritic destruction and increased glial activity are also significant following rhizotomy.
Specificity of the glial fibrillary acidic protein for astroglia.
  • A. Bignami, D. Dahl
  • Biology, Medicine
    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
  • 1977
Glial fibrillary acidic protein (GFA) is the main constituent of glial filaments and the close similarity of GFA and neurofilament protein has been recently reported. However, the immunofluorescence
Delayed astrocyte reaction following facial nerve axotomy
It is speculated that the process may protect the motor neurons during regeneration after axotomy and thus isolate the regenerating motor neurons from their afferent synaptic input.
Neurochemical and Anatomical Changes in the Dorsal Horn of Rats with an Experimental Painful Peripheral Neuropathy
Many of the neuropathic pain states that occur when human somatosensory nerves are damaged by disease or trauma are thought to involve pathological changes within the spinal segments innervated by