Staining of Skin with Dihydroxyacetone

@article{Wittgenstein1960StainingOS,
  title={Staining of Skin with Dihydroxyacetone},
  author={Eva Wittgenstein and Helen K. Berry},
  journal={Science},
  year={1960},
  volume={132},
  pages={894 - 895}
}
The reaction of skin with dihydroxyacetone to produce a brown "artificial tan" appears to proceed through combination with free amino groups in skin proteins, and particularly by combination of dihydroxyacetone with the free guanido group in arginine. 

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Paper Mentions

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Experimental Observations On Melanoidin Formation in Human Carious Teeth
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In a series of in vitro studies in this laboratory, pigment was produced synthetically in noncarious human teeth by methods which involved the interaction between degradation products of glucose and the protein component of the organic matrix. Expand
The dihydroxyacetone was generouslv furnished by
    This woik was sulppoIted in part by grants Nos. A-998 and MA-1175, National Institute of Health
      This work was carried out under the auspices of the U.S. Atomic Energy Commission. E. Flaumenhaft acknowledges with thanks support from the National Institutes of Health