Staining, straining and restraining prions

@article{Aguzzi2008StainingSA,
  title={Staining, straining and restraining prions},
  author={Adriano Aguzzi},
  journal={Nature Neuroscience},
  year={2008},
  volume={11},
  pages={1239-1240}
}
be highly discordant with the protein-only hypothesis. In the meantime, however, much evidence has accrued to suggest that prion strain-ness may be encoded in the structure of PrPSc aggregates and might not require any additional ingredients other than PrPSc itself. A crucial hint for the latter theory came from the early finding that distinct strains… CONTINUE READING