Staging of head and neck squamous cell carcinoma using the MET oncogene product as marker of tumor cells in lymph node metastases.

@article{Cortesina2000StagingOH,
  title={Staging of head and neck squamous cell carcinoma using the MET oncogene product as marker of tumor cells in lymph node metastases.},
  author={Giorgio Cortesina and Tiziana Martone and Elena Galeazzi and Martina Olivero and Antonella De Stefani and Mario Bussi and Guido Valente and Paolo Maria Comoglio and Maria Flavia Di Renzo},
  journal={International journal of cancer},
  year={2000},
  volume={89 3},
  pages={
          286-92
        }
}
In head and neck squamous cell carcinomas (HNSCC), metastasis to cervical lymph nodes is a major determinant of patient outcome. To detect metastases, we used the MET oncogene as marker, which encodes the receptor for hepatocyte growth factor/scatter factor, mediating epithelial cell motility and invasiveness. The MET gene is expressed in epithelia and over-expressed in carcinomas of specific histotypes, but not in lymphatic tissue. A total of 151 lymph nodes from 20 squamous cell carcinomas… CONTINUE READING

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