Staging of alzheimer's disease-related neurofibrillary changes

  title={Staging of alzheimer's disease-related neurofibrillary changes},
  author={Heiko Braak and Eva Braak},
  journal={Neurobiology of Aging},
Specific immunocytochemical methods (AT8) permit evaluation of neuronal changes well before the actual formation of neurofibrillary tangles and neuropil threads. Initial changes are found in the transentorhinal region (temporal lobe). From here the destructive process encroaches upon the entorhinal region, Ammon's horn, and neocortex. Initial changes occur in comparatively young individuals and can also be observed at the same predilection sites in a few species of old aged domestic animals. In… CONTINUE READING
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