Staging of alpha-synuclein in the olfactory bulb in a model of Parkinson's disease: cell types involved.

@article{Ubedabanon2010StagingOA,
  title={Staging of alpha-synuclein in the olfactory bulb in a model of Parkinson's disease: cell types involved.},
  author={Isabel Ubeda-banon and Daniel Saiz-S{\'a}nchez and Carlos de la Rosa-Prieto and Alicia Mohedano-Moriano and Noelia Fradejas and Soledad Calvo and Luc{\'i}a Argando{\~n}a-Palacios and Susana Garc{\'i}a-Mu{\~n}ozguren and Alino Mart{\'i}nez-Marcos},
  journal={Movement disorders : official journal of the Movement Disorder Society},
  year={2010},
  volume={25 11},
  pages={1701-7}
}
Impaired olfaction is an early symptom of Parkinson's disease. The underlying neuropathology likely includes alpha-synucleinopathy in the olfactory bulb at an earlier stage (Braak's stage1) than pathology in the substantia nigra, which is not observed until stage 3. In this report, we investigated the distribution and cell types affected by alpha-synuclein in the olfactory bulb of transgenic mice (2-8 months of age) expressing the human A53T variant of alpha-synuclein. alpha-Synuclein… CONTINUE READING
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