Staging of Alzheimer-related cortical destruction.

  title={Staging of Alzheimer-related cortical destruction.},
  author={Heiko Braak and Eva Braak},
  journal={International psychogeriatrics},
  volume={9 Suppl 1},
  pages={257-61; discussion 269-72}
Currently used criteria for neuropathological diagnosis of Alzheimer's disease (AD) allow only the distinction of fully developed AD or ill-defined cases with less severe pathologic alterations. There is a need for a staging procedure that is able to supplement the currently used criteria, to allow for sufficient differentiation between the initial and intermediate stages of the illness, and to provide a characterization of the degree of involvement in the brain tissue of "nondemented, age… CONTINUE READING
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